A career in teaching can be one of the most rewarding. Find out how you can be part of it.
The College will close for the Easter break on Thursday, 29 March at 3.15pm. We will reopen at 8.20am on Monday, 9 April. We wish all our students and their families a very Happy Easter!
If you are interested in training to teach, and particularly if you’d like to start training in September 2018, this event is for you! Train to Teach Derby, Landau Forte College, 2nd May 2018 4.30pm to 8pm. This event willprovide you with a wealth of information on how to get into teaching and how to…
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On Tuesday 13thMarch, Mrs Kenworthy and six Year 8 students visited Allestree Woodlands School to take part in a heat of the IET Faraday Challenge – a demanding engineering-based competition. The Faraday Challenge is an exciting initiative by the Institute of Engineering and Technology (IET) which aims to encourage more young people to consider a…
Last week, Ellie in year 8 cut an impressive 30cm from her hair for the charity ‘The Little Princess Trust.’ The charity makes wigs for children who have lost their hair due to cancer treatment. Ellie also raised nearly £1200 for the charity in sponsorship. We are all incredibly proud of Ellie’s achievement! In addition…
| Important Information
Due to the severe weather warnings issued for Saturday 17 March 2018 the decision has been made to cancel the Bronze Duke of Edinburgh practice walk to Dovedale. The Peak District is already very wet and with snow forecast and high winds, we do not think the students will get any benefit from the navigation…
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Other resources you may find useful can be found on our Ofsted page .
We are looking for experienced individuals to volunteer their time as members of our Local Governing Body.
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Aberrant energy metabolism represents a hallmark of cancer and contributes to numerous aggressive behaviors of cancer cells, including cell death and survival. Despite the poor prognosis of mantle cell lymphoma (MCL), due to the inevitable development of drug resistance, metabolic reprograming of MCL cells remains an unexplored area. Posttranslational modification of proteins via O- GlcNAcylation is an ideal sensor for nutritional changes mediated by O -GlcNAc transferase (OGT) and is removed by O -GlcNAcase (OGA). Using various small-molecule inhibitors of OGT and OGA, we found for the first time that O- GlcNAcylation potentiates MCL response to bortezomib. CRISPR interference of MGEA5 (encoding OGA) validated the apoptosis sensitization by O- GlcNAcylation and OGA inhibition. To identify the potential clinical candidates, we tested MCL response to drug-like OGA inhibitor, ketoconazole, and verified that it exerts similar sensitizing effect on bortezomib-induced apoptosis. Investigations into the underlying molecular mechanisms reveal that bortezomib and ketoconazole act in concert to cause the accumulation of truncated Bid (tBid). Not only does ketoconazole potentiate tBid induction, but also increases tBid stability through O- GlcNAcylation that interferes with tBid ubiquitination and proteasomal degradation. Remarkably, ketoconazole strongly enhances bortezomib-induced apoptosis in de novo bortezomib-resistant MCL cells and in patient-derived primary cells with minimal cytotoxic effect on normal peripheral blood mononuclear cells and hepatocytes, suggesting its potential utility as a safe and effective adjuvant for MCL. Together, our findings provide novel evidence that combination of bortezomib and ketoconazole or other OGA inhibitors may present a promising strategy for the treatment of drug-resistant MCL. Mol Cancer Ther; 17(2); 484–96. ©2017 AACR .
Note: Supplementary data for this article are available at Molecular Cancer Therapeutics Online (http://mct.aacrjournals.org/).Note:
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Companies in certain high-risk categories—such as toys, pressure vessels, elevators, gas appliances, and electrical and medical devices—wanting to do business in Europe must comply with
Conformité Europeënne Mark (CE Mark)
requirements. One way for organizations to comply is to have their management system certified by a third-party audit organization to management system requirement criteria (such as
). Customers may suggest or require that their suppliers conform to ISO 9001, ISO 14001, or safety criteria, and federal regulations and requirements may also apply. A third-party audit normally results in the issuance of a certificate stating that the auditee organization management system complies with the requirements of a pertinent standard or regulation. Third-party audits for system certification should be performed by organizations that have been evaluated and accredited by an established accreditation board, such as the
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Performance versus compliance/conformance audits
Various authors use the following terms to describe an audit purpose beyond compliance and conformance: value-added assessments, management audits, added value auditing, and continual improvement assessment. The purpose of these audits goes beyond traditional compliance and conformance audits. The audit purpose relates to organization performance. Audits that determine compliance and conformance are not focused on good or poor performance. Yet performance is an important concern for most organizations.
A key difference between compliance/conformance audits and audits designed to promote improvement is the collection of audit evidence related to organization performance versus evidence to verify conformance or compliance to a standard or procedure. An organization may conform to its procedures for taking orders, but if every order is subsequently changed two or three times, management may have cause for concern and want to rectify the inefficiency.
A product, process, or system audit may have findings that require correction and corrective action. Since most corrective actions cannot be performed at the time of the audit, the audit program manager may require a follow-up audit to verify that corrections were made and corrective actions were taken. Due to the high cost of a single-purpose follow-up audit, it is normally combined with the next scheduled audit of the area. However, this decision should be based on the importance and risk of the finding.
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For the human race...
The Terrible Secret of Lunastus is a zany comedy-action romp through the outers of space! The Moon is falling from orbit and on the eve of the Earth’s destruction four astronauts, accompanied by their robot, Android, depart for the planet Lunastus to assess its suitability as a new home for the human race. The creatures they discover there will make them question their free will… and fear for their lives.
The show was performed over four weekends at the beautiful historic Zion Lutheran Church in downtown Baltimore. The Terrible Secret of Lunastus is the third original rock opera written and performed by the Baltimore Rock Opera Society. It originally debuted in 2011 as a part of the BROS Double Feature at the Autograph Playhouse on 25th Street.
Incredibly Dead! is a b-horror homage with dastardly heroes, maniacal villains, and insane antics!
Arena Players, Baltimore's historic African American community theater, and Baltimore Rock Opera Society are partnering on an epic night of double-header theater entertainment!
Lunastus is a zany comedy-action romp through the outers of space that pays homage to our favorite science fiction serial TV shows! Get ready to explore a bizarre new world!
This violent, raucous, rebellious rock roll musical begins in 1661 in Calais, France, and crosses the open Atlantic Ocean before coming to a bloody close in the Caribbean Sea.
Amphion delivers blood, gore, tears, sweaty dancing, gore, sweet sweet romance and gore wrapped up in an epic historical fairy tale.
CHRONOSHRED is an action-packed sci-fi comedy that feels like watching all of your favorite Saturday morning cartoons – 3000 years into the future!
These smooth, crisp, refreshing rock operas are filled to the brim with deep, handcrafted flavor. The Rock Opera 6-Pack: “Oh boy, what a show!”
An electronic revolution set in the neon future of Ancient Egypt.
Our debut medieval fantasy rock opera, updated and re-imagined as a mind-blowing touring production.
MURDERCASTLE is a bone-chilling tale of death, love, and intrigue set during the Chicago 1893 World’s Fair.
VALHELLA: The Ragnarøkkoperetta is the first sign of the apocalypse – a Norse-inspired creation tale!